منابع مشابه
Management of Secretory Diarrhea
“Diarrhea is the passage of 3 or more loose or liquid stool per day, or more frequently than is normal for the individual. It is usually a symptom of gastrointestinal infection, which can be caused by a variety of bacterial, viral and parasitic organisms, infection is spread through contaminated food or drinking-water, or from person to person as a result of poor hygiene” (WHO). Diarrheal disea...
متن کاملMechanisms of Secretory Diarrhea Caused by Bacterial Enterotoxins
Among the various factors that are known to initiate the pathophysiological events leading to chronic, intractable diarrhea of infancy are intestinal infections by bacteria. Such infections, furthermore, are particularly worrisome in malnourished infants, where they tend to result more often in protracted diarrhea necessitating vigorous and risk-laden supportive treatment. Schematically, bacter...
متن کاملGut Microbial Succession Follows Acute Secretory Diarrhea in Humans
UNLABELLED Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities respond to diarrheal disease and its treatment. Here, we report that after Vibrio cholerae infecti...
متن کاملAlternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors.
Diarrhea remains the number one killer of children less than 5 years of age throughout the world. A large number of organisms are responsible including viruses (rotaviruses), bacteria (Escherichia coli and cholera vibrios) and parasites. It may not be obvious to most people but we are living during the sixth pandemic of cholera in modern memory. This pandemic started in the Celebes Islands in t...
متن کاملLysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized primarily at the apical or luminal surfaces of epithelial cells that line the airway, gut, and exocrine glands; it is well established that CFTR plays a pivotal role in cholera toxin (CTX)-induced secretory diarrhea. Lysophosphatidic acid (LPA), a naturally occurring phospholipid presen...
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ژورنال
عنوان ژورنال: Gut
سال: 1981
ISSN: 0017-5749
DOI: 10.1136/gut.22.8.695